ginsenoside Rh2, ginsenoside-Rh2
| Name | 20(s)-ginsenoside Rh2 | ||
| PubChem CID | 119307 | ||
| Molecular Weight | 622.9g/mol | ||
| Synonyms |
ginsenoside Rh2, ginsenoside-Rh2 |
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| Formula | C₃₆H₆₂O₈ | ||
| SMILES | CC(=CCCC(C)(C1CCC2(C1C(CC3C2(CCC4C3(CCC(C4(C)C)OC5C(C(C(C(O5)CO)O)O)O)C)C)O)C)O)C | ||
| InChI | 1S/C36H62O8/c1-20(2)10-9-14-36(8,42)21-11-16-35(7)27(21)22(38)18-25-33(5)15-13-26(32(3,4)24(33)12-17-34(25,35)6)44-31-30(41)29(40)28(39)23(19-37)43-31/h10,21-31,37-42H,9,11-19H2,1-8H3/t21-,22+,23+,24-,25+,26-,27-,28+,29-,30+,31-,33-,34+,35+,36-/m0/s1 | ||
| InChIKey | CKUVNOCSBYYHIS-IRFFNABBSA-N | ||
| CAS Number | 78214-33-2 | ||
| ChEMBL ID | CHEMBL1783834 | ||
| ChEBI ID | CHEBI:77147 | ||
| KEGG ID | C22128 | ||
| Structure | 
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Download
2D
MOL
3D
MOL
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| Chineses Pinyin | RenShenYe | ||
| Use Part | Leaf | ||
| Habitat | JiLin, LiaoNing, HeiLongJiang | ||
| Flavor | Bitter, Sweet | ||
| Meridian Tropism | Lung, Stomach | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Apiales
-->Family: Araliaceae
-->Genus: Panax
-->Species: Panax ginseng
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| Chineses Pinyin | RenShen | ||
| Use Part | Root | ||
| Habitat | JiLin, LiaoNing, HeiLongJiang | ||
| Flavor | Sweet, Mildly bitter | ||
| Meridian Tropism | Spleen, Lung, Heart, Kidney | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Apiales
-->Family: Araliaceae
-->Genus: Panax
-->Species: Panax ginseng
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| Chineses Pinyin | RenShenLu | ||
| Use Part | Rhizome | ||
| Habitat | JiLin, LiaoNing, HeiLongJiang | ||
| Flavor | Sweet, Mildly bitter | ||
| Meridian Tropism | Stomach, Spleen, Lung | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Apiales
-->Family: Araliaceae
-->Genus: Panax
-->Species: Panax ginseng
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| Pair Name | 20(s)-ginsenoside Rh2, TNF-related apoptosis inducing ligand | |||
| Partner Name | TNF-related apoptosis inducing ligand | |||
| Disease Info | [ICD-11: 2C12] | Hepatocellular carcinoma | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Down-regulation | Expression | BCL2 | hsa596 |
| Down-regulation | Expression | CASP3 | hsa836 | |
| Down-regulation | Cleavage | CASP8 | hsa841 | |
| Down-regulation | Cleavage | PARP1 | hsa142 | |
| Up-regulation | Expression | TNFRSF10B | hsa8795 | |
| Down-regulation | Expression | XIAP | hsa331 | |
| In Vitro Model | Hep-G2 | Hepatoblastoma | Homo sapiens (Human) | CVCL_0027 |
| OV2944-LM-3 | Malignant ovarian neoplasm | Mus musculus (Mouse) | CVCL_E956 | |
| L-02 | Human papillomavirus-related cervical adenocarcinoma | Homo sapiens (Human) | CVCL_6926 | |
| In Vivo Model | Human hepatocellular carcinoma cells HepG2 (5×10⁵) in the log phase were implanted subcutaneously (s.c.) in the flanks of mice. | |||
| Result | Our study indicates that Rh2 may act as a sensitizer in combination with TRAIL to increase the efficacy of its anti-tumor activity. | |||
